Weight Loss Shots: Complete 2026 Guide to Injections That Actually Work

Available online. Shipped directly to your door anywhere in the US.

The weight loss shot revolution

Weight loss shots have transformed obesity treatment. These once-weekly injections produce weight loss that was previously only possible with bariatric surgery — 15-22% of body weight — without the risks of surgery. Over 5 million Americans are currently using GLP-1 weight loss shots, making them the most popular weight loss treatment in history.

This guide covers everything you need to know about weight loss shots: which ones work, how they compare, what they cost, and how to get them.

Types of weight loss shots

1. Semaglutide (Wegovy, Ozempic)

Weight loss: 15% | FDA-approved: Yes | Frequency: Weekly

The most well-known weight loss shot. Wegovy is FDA-approved for weight loss; Ozempic is FDA-approved for type 2 diabetes. In the STEP trials, semaglutide produced 15% average weight loss over 68 weeks. Read our Ozempic Guide and Dosage Guide.

2. Tirzepatide (Zepbound, Mounjaro)

Weight loss: 22.5% | FDA-approved: Yes | Frequency: Weekly

The most effective weight loss shot ever created. Dual GIP/GLP-1 receptor agonist. In the SURMOUNT trials, tirzepatide produced 22.5% average weight loss over 72 weeks — about 54 pounds for a 240-pound person. Read our Zepbound vs Wegovy Guide.

3. Compounded semaglutide

Weight loss: 15% (same as Wegovy) | Cost: $150-400/month | No insurance needed

Same active ingredient as Wegovy, made by compounding pharmacies. Legal during brand-name shortages. Available through telehealth at a fraction of the cost. Read our Compounded vs Brand Guide.

4. Liraglutide (Saxenda)

Weight loss: 8% | FDA-approved: Yes | Frequency: Daily

Older GLP-1 shot requiring daily injections. Less effective than weekly options and less convenient. Being phased out in favor of semaglutide and tirzepatide.

How weight loss shots work

1. Reduce appetite: GLP-1 receptors in the brain signal fullness, dramatically reducing hunger
2. Slow stomach emptying: Food stays in the stomach longer, keeping you satisfied
3. Improve insulin sensitivity: Cells respond better to insulin, reducing fat storage
4. Reduce cravings: Many users lose interest in sugary and processed foods
5. Target visceral fat: Specifically reduces dangerous belly fat

Weight loss shots compared

• Tirzepatide (Zepbound): 22.5% weight loss | $1,000-1,400/month | Weekly
• Semaglutide (Wegovy): 15% weight loss | $1,300/month | Weekly
• Compounded semaglutide: 15% weight loss | $150-400/month | Weekly
• Liraglutide (Saxenda): 8% weight loss | $1,200/month | Daily

For most people, compounded semaglutide offers the best value. Read our Cheapest GLP-1 Guide.

Who qualifies for weight loss shots?

• BMI 30 or higher: Automatically qualifies
• BMI 27+ with a weight-related condition: High blood pressure, high cholesterol, type 2 diabetes, sleep apnea, or heart disease
• Age 18+
• No contraindications: No personal/family history of medullary thyroid cancer or MEN 2

Check your BMI with our BMI Calculator.

How to get weight loss shots online

1. Complete a health assessment: Answer questions about your weight, health, and goals
2. Meet with a provider: A US-licensed healthcare provider reviews your case
3. Get approved: If you qualify, your prescription is written
4. Medication shipped: Your shots are shipped to your door with instructions
5. Weekly self-injection: Simple pen device, injected under the skin of the abdomen, thigh, or arm
6. Ongoing support: Regular check-ins with your provider

The entire process takes 1-2 weeks. Read our Online Prescription Guide.

What to expect: results timeline

• Week 1-4: Appetite reduction begins. 2-5 lb weight loss.
• Month 1-3: Steady 1-2 lb/week. 8-15 lb total. Side effects subside.
• Month 3-6: 15-25 lb total. Significant clothing size changes.
• Month 6-12: 25-40 lb total. Approaching 10-15% weight loss.
• Month 12-18: 40-55 lb total. Maximum results: 15-22% weight loss.

Read our Before and After Guide and 1-Month Results Guide.

Side effects and management

Common side effects

• Nausea (30-40%): Eat smaller meals, avoid fatty foods, stay hydrated
• Diarrhea (20%): Avoid spicy foods, eat soluble fiber
• Vomiting (15-20%): Reduce portions, eat bland foods temporarily
• Constipation (10-15%): Drink water, eat fiber, exercise
• Stomach pain: Usually mild, improves over time

Most side effects improve within 4-8 weeks. Starting at a low dose and gradually increasing minimizes side effects. Read our Side Effects Guide.

Rare but serious risks

• Pancreatitis (0.2% risk)
• Gallbladder disease (2% risk)
• Thyroid tumors (seen in rodents, not confirmed in humans)
• Kidney problems (from severe dehydration)

How to inject weight loss shots

1. Wash hands: Clean hands and injection site
2. Choose injection site: Abdomen (2 inches from navel), thigh, or upper arm
3. Rotate sites: Use a different site each week to prevent irritation
4. Clean the site: Use an alcohol swab
5. Inject: Press the pen against the skin and press the button — the needle is very small
6. Hold for 10 seconds: Ensure full dose is delivered
7. Dispose safely: Use a sharps container

The injection is virtually painless — the needle is smaller than a human hair. Most people feel nothing or a tiny pinch.

How to maximize shot results

1. High-protein diet: 1.2-1.6g/kg — use our Protein Calculator
2. Calorie deficit: Use our Calorie Deficit Calculator
3. Exercise: 3x strength + 2x HIIT + daily walking — read our Exercise Guide
4. Follow the GLP-1 diet: Read our GLP-1 Diet Guide
5. Stay hydrated: 80-100 oz water per day
6. Sleep 7-9 hours: Poor sleep sabotages weight loss
7. Take photos: Document your transformation

Weight loss shots vs. other treatments

• Diet + exercise alone: 5-10% weight loss
• Weight loss apps (Noom): 5-7% — read our Noom Guide
• Metformin: 2-3% — read our Metformin Guide
• Berberine: 2-3% — read our Berberine Guide
• Semaglutide shots: 15% weight loss
• Tirzepatide shots: 22.5% weight loss
• Bariatric surgery: 25-30% weight loss

Cost and insurance

• Wegovy without insurance: ~$1,300/month
• Zepbound without insurance: ~$1,000-1,400/month
• With insurance: As low as $25/month for eligible patients
• Compounded semaglutide: $150-400/month, no insurance needed
• Manufacturer savings cards: Available for brand-name medications

Read our Cost Guide and Wegovy Without Insurance Guide.

The bottom line

Weight loss shots — semaglutide (Wegovy) and tirzepatide (Zepbound) — are the most effective weight loss treatment available, producing 15-22% body weight loss in clinical trials. These once-weekly injections reduce appetite, improve insulin sensitivity, and target visceral fat. Available through online telehealth with US-licensed providers, with compounded semaglutide offering an affordable option at $150-400/month. The injection is painless and takes 10 seconds. Combine with a high-protein diet, calorie deficit, and exercise for maximum results. Check your eligibility today and read our Injections Guide for more details.