Amycretin: Novo's Amylin + GLP-1 Fusion — 13% in 12 Weeks (2026)
Injectable and oral. The fastest weight-loss data Novo has ever published — what amycretin is, when it lands, and what works while you wait.
Lose 15-22% body weight with doctor-backed GLP-1s
Compounded semaglutide & tirzepatide from $350/mo $119/mo. Free online consultation with a US-licensed provider. If approved, medication ships to your door in 3-5 days. No insurance needed.
⚡ Limited spots this month — 50,000+ patients already started
See if I qualify — Free consultationAvailable online · Shipped to your door anywhere in the US
Paid partnership · Prescription product requiring a physician consultation · Not everyone qualifies · Results vary
Quick answer:
Amycretin is Novo's single-molecule GLP-1 + amylin agonist — ~13% weight loss in 12 weeks in early trials, injectable AND oral versions. Availability ~2028+. Meanwhile, tirzepatide delivers ~20% now — check eligibility free.
What makes amycretin different
Every current GLP-1 hits one satiety pathway — or two, if it's tirzepatide (GIP+GLP-1). Amycretin hits GLP-1 + amylin, like CagriSema — except it's engineered as a single molecule, not a co-administered combo. That simplification matters: one manufacturing process, one injection, and critically — an oral pill version in parallel development.
- Injectable: ~13.1% weight loss in 12 weeks (early readout) — unprecedented speed
- Oral: ~13.1% at 12 weeks in a small Phase 1 cohort — a pill matching early injectable curves would be category-changing
Context: how fast is 13% in 12 weeks?
| Drug | ~12-week result | Full-trial result |
|---|---|---|
| Amycretin (injectable) | ~13% | TBD — Phase 3 pending |
| Wegovy (semaglutide) | ~5-6% | ~15-17% at 68 wks |
| Zepbound (tirzepatide) | ~8% | ~20-21% at 72 wks |
| CagriSema | ~9-10% | ~23% at 68 wks |
Caveat: early-phase data, small cohorts, no full-duration results yet. The curve will flatten — the question is where it lands relative to ~23%.
Amycretin vs CagriSema: Novo's internal race
- CagriSema = two molecules (semaglutide + cagrilintide), injectable only, nearer approval (2026-27)
- Amycretin = one fusion molecule, injectable AND oral, deeper pipeline (~2028)
- If amycretin's oral version pans out, it could eventually cannibalize CagriSema — Novo is running both
Today's options already deliver 15-22%
Tirzepatide & semaglutide prescribed online — from $119/mo, ships in days. Free eligibility check.
Check my eligibility — freeSide effects: what early data shows
Same class profile — nausea, vomiting, GI discomfort during titration, mostly mild-to-moderate. Nothing unexpected yet; larger trials will clarify rates. See the current class breakdown in GLP-1 side effects.
Frequently asked questions
What is amycretin?
Novo's single-molecule GLP-1 + amylin agonist — injectable and oral formulations in development.
How much weight loss?
~13% in 12 weeks in early data — the fastest pace published. Full-trial numbers pending.
When will it launch?
~2028+ realistically. CagriSema comes first (2026-27).
Better than Ozempic/Zepbound?
Faster early curve than anything published — final ranking awaits Phase 3.
Amycretin vs CagriSema?
Amycretin = one molecule + oral option; CagriSema = two molecules, injectable only, sooner.
Bottom line
Amycretin is Novo's most exciting asset — but it's years away. Treatment that works is available today: check eligibility free. Related: CagriSema, retatrutide, orforglipron, GLP-1 pipeline.
Related reading
Lose 15-22% body weight — GLP-1s from $119/month
Compounded semaglutide & tirzepatide prescribed online by US-licensed providers. No insurance needed — medication shipped to your door in 3-5 days.
⚡ Limited spots this month — 50,000+ patients already started
See if I qualify — Free consultationFrom $119/month · No insurance needed · Ships nationwide in 3-5 days · Paid partnership · Results vary
Doctor-backed GLP-1 weight loss from $119/month
Compounded semaglutide & tirzepatide. Online consultation with a US-licensed provider. No insurance needed.
⚡ Limited spots this month — 50,000+ patients already started
Paid partnership · Prescription product · Not everyone qualifies · Results vary
Real patients. Real results.
Join 50,000+ patients who transformed their lives with GLP-1 medications
"I tried everything — keto, intermittent fasting, gym memberships. Nothing worked long-term. GLP-1 changed everything. I lost 47 pounds in 8 months and finally feel like myself again. The online process was so easy — I had my prescription in 2 days."
Jessica M., 38
Texas
-47 lbs
in 8 months
Compounded semaglutide
"At 52, my doctor said I was heading toward diabetes. I started tirzepatide through a telehealth program and lost 62 pounds. My A1C is back to normal, my blood pressure dropped, and I'm off two medications. Wish I'd done this years ago."
David R., 52
Florida
-62 lbs
in 11 months
Tirzepatide (Zepbound)
"I was skeptical about doing this online, but the whole process was professional and easy. My provider answered all my questions, and the medication arrived in 4 days. I've lost 38 pounds and finally have energy to play with my kids again."
Aisha K., 34
California
-38 lbs
in 6 months
Compounded semaglutide
Results vary. These testimonials reflect individual experiences and are not typical. Weight loss depends on diet, activity, and adherence to medication.
How it works — 3 simple steps
Take the 60-second quiz
Answer a few questions about your health, weight goals, and medical history. It's free and confidential.
1 min
Meet your US-licensed provider
A board-certified clinician reviews your profile and prescribes the right GLP-1 medication for you — entirely online.
24-48 hrs
Get medication shipped to your door
Your prescription is filled by a US pharmacy and delivered in discreet packaging in 3-5 business days.
3-5 days
What's your #1 weight loss goal?
This helps us match you with the right medication type.