GLP-1 Medication Chart: Complete Comparison of All GLP-1 Drugs in 2026
Complete GLP-1 medication chart comparing Wegovy, Ozempic, Zepbound, Mounjaro, Rybelsus, Saxenda, Trulicity, and Foundayo.
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Quick answer: GLP-1 medication chart
There are 8 major GLP-1 medications available in the US in 2026. Tirzepatide (Zepbound, Mounjaro) produces the most weight loss at up to 22.5%. Semaglutide (Wegovy, Ozempic) produces approximately 15%. The cheapest option is compounded semaglutide at $149/month. Foundayo (orforglipron) is the newest oral GLP-1, approved in April 2026. Use the chart below to compare all medications side by side.
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Complete GLP-1 medication comparison chart
| Medication | Active Ingredient | FDA Approval | Route | Dosing | Avg Weight Loss | Cost/Month (No Insurance) |
|---|---|---|---|---|---|---|
| Wegovy | Semaglutide | Weight management | Weekly injection | Up to 2.4 mg/week | ~15% | $199–$1,349 |
| Ozempic | Semaglutide | Type 2 diabetes | Weekly injection | Up to 2 mg/week | ~14% (off-label) | $892–$1,400 |
| Zepbound | Tirzepatide | Weight management, OSA | Weekly injection | Up to 15 mg/week | Up to 22.5% | $299–$1,059 |
| Mounjaro | Tirzepatide | Type 2 diabetes | Weekly injection | Up to 15 mg/week | ~20% (off-label) | $1,023–$1,029 |
| Rybelsus | Semaglutide | Type 2 diabetes | Daily oral tablet | Up to 14 mg/day | ~4–6% (T2D dose) | $800–$950 |
| Saxenda | Liraglutide | Weight management | Daily injection | Up to 3 mg/day | ~8% | $1,300+ |
| Trulicity | Dulaglutide | Type 2 diabetes | Weekly injection | Up to 4.5 mg/week | ~5% (T2D dose) | $800–$970 |
| Foundayo | Orforglipron | Weight management (2026) | Daily oral tablet | Up to 36 mg/day | ~12–13% | ~$149 |
| Compounded semaglutide | Semaglutide | Not FDA-approved | Weekly injection | Up to 2.4 mg/week | ~15% (expected) | $149–$299 |
Weight loss percentages are from pivotal clinical trials. Individual results vary. See our GLP-1 cost guide for detailed pricing.
Side effects comparison
| Medication | Nausea | Diarrhea | Constipation | Vomiting |
|---|---|---|---|---|
| Semaglutide (Wegovy) | 44% | 31% | 24% | 24% |
| Tirzepatide (Zepbound) | 25–31% | 18–23% | 11–17% | 6–12% |
| Liraglutide (Saxenda) | 35% | 21% | 19% | 12% |
| Orforglipron (Foundayo) | 25–30% | 15–20% | 10–15% | 8–12% |
How to choose the right GLP-1 medication
- Maximum weight loss: Choose tirzepatide (Zepbound) — up to 22.5% weight loss
- Lowest cost: Choose compounded semaglutide ($149–$299/month) or Foundayo (~$149/month)
- Oral preference: Choose Wegovy oral tablet, Rybelsus, or Foundayo
- Fewest side effects: Tirzepatide may have slightly fewer GI side effects than semaglutide
- Cardiovascular benefit: Semaglutide has the strongest cardiovascular evidence (SELECT trial)
- Sleep apnea: Zepbound is FDA-approved for obstructive sleep apnea in adults with obesity
- Insurance coverage: Check which medications your plan covers — Wegovy and Zepbound are most commonly covered
For a full comparison, see our GLP-1 comparison guide 2026 and best GLP-1 for weight loss guide.
FAQ
Which GLP-1 has the most weight loss?
Tirzepatide (Zepbound, Mounjaro) at up to 22.5%, followed by semaglutide (Wegovy) at ~15%.
Which GLP-1 is cheapest?
Compounded semaglutide ($149–$299/month) and Foundayo (~$149/month through LillyDirect).
Which are FDA-approved for weight loss?
Wegovy, Zepbound, Saxenda, and Foundayo. Ozempic and Mounjaro are approved for T2D but often used off-label.
What is the difference between Wegovy and Ozempic?
Both contain semaglutide. Wegovy is approved for weight management (2.4 mg), Ozempic for T2D (2 mg).
Is there an oral GLP-1?
Yes: Rybelsus (T2D), Wegovy oral tablets (weight management), and Foundayo (weight management, 2026).
Which has the fewest side effects?
Real-world data suggests tirzepatide may cause fewer GI side effects than semaglutide (28.5% vs 50.7%).
Can I switch between GLP-1 medications?
Yes. Your provider will guide the transition, which may involve starting at a lower dose of the new medication.
What is Foundayo?
Foundayo (orforglipron) is the first oral small-molecule GLP-1, approved April 2026 for weight management. ~12–13% weight loss, ~$149/month.
Related articles
Lose 15-22% body weight — GLP-1s from $147/month
Compounded semaglutide & tirzepatide prescribed online by US-licensed providers. No insurance needed — medication shipped to your door in 3-5 days.
⚡ Limited spots this month — 50,000+ patients already started
See if I qualify — Free consultationFrom $147/month · No insurance needed · Ships nationwide in 3-5 days · Paid partnership · Results vary
Doctor-backed GLP-1 weight loss from $147/month
Compounded semaglutide & tirzepatide. Online consultation with a US-licensed provider. No insurance needed.
⚡ Limited spots this month — 50,000+ patients already started
Paid partnership · Prescription product · Not everyone qualifies · Results vary
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Jessica M., 38
Texas
-47 lbs
in 8 months
Compounded semaglutide
"At 52, my doctor said I was heading toward diabetes. I started tirzepatide through a telehealth program and lost 62 pounds. My A1C is back to normal, my blood pressure dropped, and I'm off two medications. Wish I'd done this years ago."
David R., 52
Florida
-62 lbs
in 11 months
Tirzepatide (Zepbound)
"I was skeptical about doing this online, but the whole process was professional and easy. My provider answered all my questions, and the medication arrived in 4 days. I've lost 38 pounds and finally have energy to play with my kids again."
Aisha K., 34
California
-38 lbs
in 6 months
Compounded semaglutide
Results vary. These testimonials reflect individual experiences and are not typical. Weight loss depends on diet, activity, and adherence to medication.
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