Wegovy Dosing Chart 2026: Complete Titration Schedule

Quick answer: The Wegovy dosing chart

Wegovy (semaglutide 2.4 mg) follows a 5-step titration schedule over 20 weeks, starting at 0.25 mg weekly and increasing every 4 weeks until reaching the 2.4 mg maintenance dose. In 2026, the FDA also approved Wegovy HD at 7.2 mg for patients who need additional weight loss after tolerating 2.4 mg.

The complete Wegovy dosing chart

Wegovy HD: the 7.2 mg high-dose option

In March 2026, the FDA approved Wegovy HD (semaglutide 7.2 mg) — the highest-efficacy injectable GLP-1 available. In the STEP UP trial:

• 20.7% average weight loss over 72 weeks
• 1 in 3 patients lost 25% or more of starting body weight
• Eligibility requires tolerating 2.4 mg for at least 4 weeks
• Cash price through NovoCare: approximately $399/month

Wegovy HD is a step-up from the standard 2.4 mg dose, not a starting dose. Your doctor will only prescribe it if you've been stable on 2.4 mg and need additional weight loss.

How to inject Wegovy: step by step

Wegovy is a subcutaneous injection given once weekly. Here's the proper protocol:

1. Choose your injection site: abdomen, thigh, or upper arm. Rotate sites each week.
2. Check the pen: ensure the solution is clear and colorless. Do not use if cloudy.
3. Attach a new needle: use a new needle for each injection.
4. Prime the pen: follow the pen's instructions to prime before first use.
5. Inject: insert the needle at a 90-degree angle. Press the plunger fully and hold for 5-10 seconds.
6. Remove and dispose: remove the needle and dispose of it in a sharps container.

Wegovy can be taken at any time of day, with or without food. Consistency is key — try to take it on the same day each week.

Managing side effects during titration

The gradual titration schedule exists specifically to minimize side effects. Here's how to manage the most common ones:

Wegovy dosing vs other GLP-1s

What to do if you miss a dose

Wegovy has a built-in grace period. If you miss your scheduled dose:

• Less than 5 days late: Take it as soon as you remember, then continue your regular schedule.
• More than 5 days late: Skip the missed dose and take your next dose on the regular schedule.
• Never double dose: Do not take two doses in the same week to make up for a missed one.

If you miss more than 2 weeks, contact your healthcare provider. They may recommend restarting at a lower dose.

The bottom line

Wegovy's dosing chart is designed for gradual, safe escalation. The 5-step titration from 0.25 mg to 2.4 mg minimizes side effects, and the new 7.2 mg HD option offers additional weight loss for those who need it. The key to success is consistency: take your dose weekly, manage side effects proactively, and work with your healthcare provider to find the right maintenance dose for your goals.