TB-500 Dosage: Loading, Maintenance & Cycle Guide (2026)

Short answer

The community standard: 2-5 mg per dose, once or twice weekly — 4-10 mg total per week during loading. TB-500 is dosed in milligrams, not micrograms, because it's a bigger molecule acting systemically over a longer window. The classic structure is a 4-6 week loading phase followed by lower maintenance dosing or an off-cycle.

Phase structure

The logic: loading saturates the systemic repair signaling (cell migration, actin regulation) while the injury remodels; maintenance sustains a lower background level. Whether the phased approach is strictly necessary is unknown — it's community convention, not trial-validated.

Why injection site doesn't matter

BPC-157 users obsess over injecting near the injury because its effect is largely local. TB-500 is the opposite: it promotes cell migration throughout the body — repair cells travel to damage regardless of where the peptide entered. Any subcutaneous site is equivalent; rotate only for comfort.

Vial math (10 mg format)

Because weekly totals are 4-10 mg, the 10 mg vial is the practical size. Reconstitute with 2 mL bacteriostatic water → 500 mcg per 0.1 mL. A 4 mg dose = 0.8 mL (80 units); a 5 mg dose = 1 mL. One 10 mg vial ≈ 1-2.5 weekly doses. Refrigerate after mixing.

The honest caveats

• No human clinical trials — every protocol is animal-data extrapolation plus community practice.
• Angiogenesis-adjacent mechanism — same theoretical concern around existing tumors as BPC-157.
• Banned in tested sport (Thymosin Beta-4 class).
• Grey-market purity is the dominant real-world risk — verified sourcing beats optimizing the milligrams.

Build a protocol estimate by goal with our peptide protocol calculator.

Related guides

• TB-500 vs BPC-157
• BPC-157 Dosage Chart
• BPC-157 Guide
• Best Recovery Peptides Ranked
• GLP-1 Stacking Peptides
• Peptide Protocol Calculator