Tirzepatide Dosage Chart 2026: Full Schedule (2.5mg to 15mg)
The complete tirzepatide escalation — six dose levels, dose-response data, compounded unit conversions, and hold/step-back rules.
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The standard titration schedule
| Step | Weekly dose | Minimum duration | SURMOUNT-1 loss @72wk |
|---|---|---|---|
| Start | 2.5 mg | 4 weeks | Tolerability only |
| 2 | 5 mg | 4+ weeks | ~15% |
| 3 | 7.5 mg | 4+ weeks | — |
| 4 | 10 mg | 4+ weeks | ~19.5% |
| 5 | 12.5 mg | 4+ weeks | — |
| Max | 15 mg | — | ~21% |
Six levels give finer control than semaglutide's five — escalate only when tolerating and needing more effect. 5mg-10mg are legitimate long-term maintenance doses.
Tirzepatide vs semaglutide dosing — the key differences
- Dual mechanism — GIP + GLP-1 agonism vs GLP-1 only
- Finer ladder — 2.5mg steps allow gentler escalation
- Higher ceiling — ~21% mean loss at 15mg vs ~15% at sema 2.4mg
- Tolerability — many report less nausea, but individual response varies
Compounded units — concentration warning
Compounded tirzepatide concentrations vary (5, 10, 20mg/mL all exist). At 10mg/mL: 2.5mg = 25 units, 5mg = 50, 10mg = 100 units (a full 1mL syringe — often split). Always dose off your vial's label — see our units guide.
Missed dose and step-back rules
Within 96 hours: take when remembered. Past that: skip, never double. After 2+ missed weeks: drop a level to re-titrate. Same logic as semaglutide — GI tolerance resets faster than people expect.
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Related guides
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Compounded semaglutide & tirzepatide prescribed online by US-licensed providers. No insurance needed — medication shipped to your door in 3-5 days.
⚡ Limited spots this month — 50,000+ patients already started
See if I qualify — Free consultationFrom $119/month · No insurance needed · Ships nationwide in 3-5 days · Paid partnership · Results vary
Doctor-backed GLP-1 weight loss from $119/month
Compounded semaglutide & tirzepatide. Online consultation with a US-licensed provider. No insurance needed.
⚡ Limited spots this month — 50,000+ patients already started
Paid partnership · Prescription product · Not everyone qualifies · Results vary
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Texas
-47 lbs
in 8 months
Compounded semaglutide
"At 52, my doctor said I was heading toward diabetes. I started tirzepatide through a telehealth program and lost 62 pounds. My A1C is back to normal, my blood pressure dropped, and I'm off two medications. Wish I'd done this years ago."
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Florida
-62 lbs
in 11 months
Tirzepatide (Zepbound)
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Aisha K., 34
California
-38 lbs
in 6 months
Compounded semaglutide
Results vary. These testimonials reflect individual experiences and are not typical. Weight loss depends on diet, activity, and adherence to medication.
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