Trulicity vs Ozempic Cost 2026: List Price, Direct-Pay, Insurance, Medicare and Cost per Result
Every price route for dulaglutide and semaglutide side by side — list, manufacturer direct, savings cards, Medicare, discount cards — plus the dollars-per-A1c-point and per-pound metrics that show which is actually cheaper.
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Compounded semaglutide & tirzepatide from $350/mo $147/mo. Free online consultation with a US-licensed provider. If approved, medication ships to your door in 3-5 days. No insurance needed.
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The cost answer
At list price Trulicity (~$977) and Ozempic (~$998) are a wash. Everywhere else, Ozempic is cheaper: $349/month direct from NovoCare or Costco with no insurance, versus ~$977 for Trulicity, which has no direct-pay program. With covered commercial insurance both reach ~$25 via savings cards. And because Ozempic lowers A1c more and produces twice the weight loss, its cost per result is a fraction of Trulicity's. Prices verified October 2026.
Trulicity vs Ozempic: every price route
| Route | Trulicity (dulaglutide) | Ozempic (semaglutide) |
|---|---|---|
| Retail list price | ~$977 / 4 pens | ~$998 / pen (4 doses) |
| Manufacturer direct self-pay | None | $349 via NovoCare |
| Warehouse club | ~$950 cash | $349 at Costco (member) |
| Discount card (GoodRx etc.) | ~$850-$950 | ~$900-$950 (worse than NovoCare) |
| Commercial insurance, covered + savings card | ~$25 (max $150 off/fill, 24 months) | ~$25 (max $150 off/fill) |
| Commercial insurance, not covered | List price; card does not apply | $349 via NovoCare |
| Medicare Part D | Tier copay ~$40-$150; coupons prohibited | Tier copay ~$40-$150; negotiated price from 2027 |
| Compounded equivalent | None (dulaglutide is not compounded) | Compounded semaglutide $69-$199 |
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Cost per result (SUSTAIN-7 head-to-head)
| Trulicity 1.5 mg | Ozempic 1 mg | |
|---|---|---|
| A1c reduction (40 wk) | -1.4 pts | -1.8 pts |
| Weight loss (40 wk) | -3.0 kg (6.6 lb) | -6.5 kg (14.3 lb) |
| Monthly self-pay | ~$977 | $349 |
| $ per A1c point / month | ~$698 | ~$194 |
| $ per lb lost / month | ~$148 | ~$24 |
Higher doses widen the gap: Trulicity 4.5 mg adds ~0.2-0.3 A1c points, while Ozempic 2 mg adds a similar amount at the same $349. Full clinical comparison in Trulicity vs Ozempic.
12-month cost by scenario
| Scenario | Trulicity | Ozempic |
|---|---|---|
| Covered commercial insurance + card | ~$300 | ~$300 |
| Medicare Part D (mid-tier copay) | ~$600-$1,800 | ~$600-$1,800 |
| Uninsured / not covered | ~$11,700 | ~$4,188 |
| Uninsured, compounded semaglutide instead | n/a | $1,428-$2,388 |
When Trulicity is the cheaper choice
- Your formulary covers Trulicity on a lower tier than Ozempic — this happens on some Medicare and employer plans; always compare your own plan's tiers.
- You have had GI intolerance to semaglutide; dulaglutide is generally better tolerated at equivalent efficacy steps.
- You need a once-weekly GLP-1 approved down to age 10 for type 2 diabetes (Trulicity is; Ozempic is adults only).
Switching to save money
Trulicity → Ozempic: skip one week, start at 0.25 mg, titrate every 4 weeks (Ozempic dosage chart). Ozempic → Trulicity (if your plan prefers it): start at 0.75 mg one week after the last Ozempic dose, then 1.5 mg. Neither switch has an official dose-equivalence; both restart at the lowest dose. See the GLP-1 switching guide.
Compare every GLP-1 by real monthly cost.
Check my eligibilityRelated guides
- Trulicity vs Ozempic: Full Comparison
- Trulicity for Weight Loss
- Wegovy vs Trulicity
- Ozempic Cost Guide
- How Much Does Mounjaro Lower A1c?
- GLP-1 Medicare Coverage 2026
- Saxenda vs Wegovy Price $349 vs $1,350 - Cost per Pound Lost Compared
- Will Ozempic Help If I Weigh 200 Pounds? Expected Loss, BMI Rules & Timeline
Lose 15-22% body weight — GLP-1s from $147/month
Compounded semaglutide & tirzepatide prescribed online by US-licensed providers. No insurance needed — medication shipped to your door in 3-5 days.
⚡ Limited spots this month — 50,000+ patients already started
See if I qualify — Free consultationFrom $147/month · No insurance needed · Ships nationwide in 3-5 days · Paid partnership · Results vary
Doctor-backed GLP-1 weight loss from $147/month
Compounded semaglutide & tirzepatide. Online consultation with a US-licensed provider. No insurance needed.
⚡ Limited spots this month — 50,000+ patients already started
Paid partnership · Prescription product · Not everyone qualifies · Results vary
Real patients. Real results.
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"I tried everything — keto, intermittent fasting, gym memberships. Nothing worked long-term. GLP-1 changed everything. I lost 47 pounds in 8 months and finally feel like myself again. The online process was so easy — I had my prescription in 2 days."
Jessica M., 38
Texas
-47 lbs
in 8 months
Compounded semaglutide
"At 52, my doctor said I was heading toward diabetes. I started tirzepatide through a telehealth program and lost 62 pounds. My A1C is back to normal, my blood pressure dropped, and I'm off two medications. Wish I'd done this years ago."
David R., 52
Florida
-62 lbs
in 11 months
Tirzepatide (Zepbound)
"I was skeptical about doing this online, but the whole process was professional and easy. My provider answered all my questions, and the medication arrived in 4 days. I've lost 38 pounds and finally have energy to play with my kids again."
Aisha K., 34
California
-38 lbs
in 6 months
Compounded semaglutide
Results vary. These testimonials reflect individual experiences and are not typical. Weight loss depends on diet, activity, and adherence to medication.
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