Wegovy vs Ozempic: What's the Difference?
Complete 2026 comparison of Wegovy vs Ozempic: dose, efficacy, side effects, cost, and FDA approval.
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Wegovy vs Ozempic: quick comparison
| Feature | Wegovy | Ozempic |
|---|---|---|
| Active ingredient | Semaglutide | Semaglutide |
| FDA approval | Weight loss (obesity) | Type 2 diabetes |
| Dose | 2.4 mg/week (also 7.2 mg HD) | 0.5, 1, 2 mg/week |
| Weight loss | ~15% (STEP-1 trial) | ~11% (SUSTAIN-1, off-label) |
| Nausea rate | 44% | 20% |
| Vomiting rate | 25% | 9% |
| Manufacturer | Novo Nordisk | Novo Nordisk |
| Insurance coverage | Often not covered (weight loss) | Often covered (diabetes) |
| Cash price | $149 (NovoCare) / $1,300 retail | $800-$950 retail |
| Frequency | Weekly injection | Weekly injection |
Why they are different despite same ingredient
Wegovy and Ozempic are essentially the same drug at different doses. Novo Nordisk obtained separate FDA approvals for different indications: Ozempic for type 2 diabetes (lower doses) and Wegovy for weight loss (higher dose). The higher dose in Wegovy produces more weight loss but also more side effects.
Side effects comparison
| Side effect | Wegovy (2.4 mg) | Ozempic (1 mg) |
|---|---|---|
| Nausea | 44% | 20% |
| Diarrhea | 30% | 9% |
| Vomiting | 25% | 9% |
| Constipation | 24% | 3% |
| Fatigue | 11% | Not common |
| Discontinuation due to GI | 4.3% | 3.8% |
Not sure which is right for you?
A US-licensed provider can help you choose between Wegovy and Ozempic based on your goals.
Check eligibilityCost comparison
| Option | Wegovy | Ozempic |
|---|---|---|
| Retail price | $1,300/month | $800-$950/month |
| With insurance | $0-$25 (if covered) | $0-$25 (if covered) |
| Cash-pay program | $149/month (NovoCare) | Not available |
| Compounded alternative | $179-$399/month | $179-$399/month |
See our Wegovy cost guide and GLP-1 cost guide for full pricing.
Which should you choose?
Choose Wegovy if:
- Your primary goal is weight loss
- You want the FDA-approved option for obesity
- You can access NovoCare ($149/month)
- Your insurance covers Wegovy
Choose Ozempic if:
- You have type 2 diabetes
- Your insurance covers Ozempic but not Wegovy
- You want fewer side effects (lower dose)
- Your provider recommends lower-dose semaglutide
Related guides
- Wegovy Cost Guide
- GLP-1 Cost Guide 2026
- GLP-1 Comparison Guide 2026
- Ozempic to Wegovy Conversion
- Semaglutide vs Tirzepatide
- Wegovy Dosage Guide
- How Much Weight Can You Lose on GLP-1
Medical disclaimer: This content is for informational purposes only. Always consult a qualified healthcare provider.
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Jessica M., 38
Texas
-47 lbs
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Compounded semaglutide
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Florida
-62 lbs
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Tirzepatide (Zepbound)
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California
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in 6 months
Compounded semaglutide
Results vary. These testimonials reflect individual experiences and are not typical. Weight loss depends on diet, activity, and adherence to medication.
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