GLP-1 Data Visualizations 2026
Original data visualizations: dosage equivalency, cost per pound lost, and treatment timeline comparisons across all GLP-1 medications.
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Original Data Visualizations
All tables and charts below are original analyses created by the Healthy-Weight research team. Data sources include published clinical trials (PubMed-cited) and our own 2026 patient survey of 1,200 GLP-1 users.
Table of contents
- 1. Dosage equivalency table
- 2. Cost per pound lost
- 3. Treatment timeline comparison
- 4. Weight loss trajectory by medication
- 5. Side effect onset and resolution timeline
- 6. Annual cost breakdown by medication
1. Dosage equivalency table
GLP-1 medications cannot be directly compared by milligram dose because they have different molecular structures, receptor affinities, and pharmacokinetics. The table below provides approximate equivalencies based on clinical trial weight loss efficacy at maintenance dose.
| Medication | Starting Dose | Mid Dose | Maintenance Dose | Max Dose | Approx. Equiv. Efficacy* | Half-Life |
|---|---|---|---|---|---|---|
| Tirzepatide (Zepbound) | 2.5mg | 7.5mg | 10-15mg | 15mg | Highest (22.5%) | ~5 days |
| Semaglutide (Wegovy) | 0.25mg | 1.0mg | 2.4mg | 2.4mg | High (14.9%) | ~165 hours |
| Liraglutide (Saxenda) | 0.6mg | 1.8mg | 3.0mg | 3.0mg | Moderate (8.0%) | ~13 hours |
| Dulaglutide (Trulicity) | 0.75mg | 1.5mg | 3.0mg | 4.5mg | Lower (4.0%) | ~5 days |
| Exenatide ER (Bydureon) | 2.0mg | 2.0mg | 2.0mg | 2.0mg | Lowest (3.7%) | ~2 weeks |
Table 1: Dosage equivalency based on clinical trial weight loss efficacy at maintenance dose. Approximate equivalency: tirzepatide 10mg is roughly equivalent to semaglutide 2.4mg in weight loss. Tirzepatide 15mg exceeds all other GLP-1 medications. Weight loss percentages are from pivotal trials (SURMOUNT-1, STEP-1, SCALE, AWARD-6, DURATION-1).
2. Cost per pound lost
This original analysis calculates the cost per pound of weight loss for each GLP-1 medication, combining clinical trial efficacy data with current market pricing (September 2026). The formula: (Monthly cost x Treatment duration) / Average total weight loss in pounds.
| Medication | Monthly Cost | Trial Duration | Avg Weight Loss | Avg Weight Loss (lbs)** | Total Cost | Cost / Pound Lost | Value Rating |
|---|---|---|---|---|---|---|---|
| Compounded Semaglutide | $147 | 6 months | 13.1% | 26.2 lbs | $882 | $34/lb | Excellent |
| Compounded Tirzepatide | $249 | 6 months | 18.5% | 37.0 lbs | $1,494 | $40/lb | Excellent |
| Zepbound (brand) | $1,059 | 18 months | 22.5% | 45.0 lbs | $19,062 | $424/lb | Fair |
| Wegovy (brand) | $1,250 | 16 months | 14.9% | 29.8 lbs | $20,000 | $671/lb | Poor |
| Saxenda (brand) | $1,350 | 13 months | 8.0% | 16.0 lbs | $17,550 | $1,097/lb | Very Poor |
Table 2: Cost per pound lost analysis. **Average weight loss in pounds assumes a starting weight of 200 lbs (average from our 1,200-patient survey). Compounded costs reflect median pricing from our 50-provider analysis. Brand costs reflect retail pricing without insurance. Value ratings: Excellent = under $50/lb, Fair = $200-$500/lb, Poor = $500-$1000/lb, Very Poor = over $1000/lb.
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3. Treatment timeline comparison
This table compares the expected treatment journey for each GLP-1 medication, from first dose through maintenance, including titration duration and milestone timing.
| Milestone | Tirzepatide | Semaglutide | Liraglutide | Dulaglutide |
|---|---|---|---|---|
| First noticeable weight loss | Week 2 | Week 2-3 | Week 3-4 | Week 4-6 |
| 5% body weight loss | Week 4-6 | Week 8 | Week 12 | Week 16-20 |
| 10% body weight loss | Week 12 | Week 20 | Week 28-32 | May not reach |
| 15% body weight loss | Week 24-36 | Week 40-48 | Not typical | Not typical |
| 20% body weight loss | Week 48-60 | Not typical | Not typical | Not typical |
| Full titration complete | Week 20 | Week 16 | Week 5 | Week 12 |
| Max weight loss achieved | Week 72 | Week 68 | Week 56 | Week 52 |
| Plateau typically begins | Month 14-16 | Month 12-14 | Month 8-10 | Month 8-10 |
Table 3: Treatment timeline comparison based on pivotal clinical trial data (SURMOUNT-1, STEP-1, SCALE, AWARD-6). Individual results vary. "Not typical" means fewer than 30% of trial participants reached this milestone.
4. Weight loss trajectory by medication
This table shows the expected cumulative weight loss percentage at key time points for each medication, based on clinical trial interim analysis data:
| Time Point | Tirzepatide 15mg | Tirzepatide 10mg | Semaglutide 2.4mg | Liraglutide 3.0mg | Dulaglutide 1.5mg |
|---|---|---|---|---|---|
| Month 1 | 2.3% | 2.1% | 2.0% | 1.5% | 0.8% |
| Month 3 | 6.5% | 5.5% | 5.0% | 3.5% | 1.8% |
| Month 6 | 12.0% | 10.5% | 8.5% | 5.5% | 2.8% |
| Month 9 | 16.0% | 14.0% | 11.0% | 6.8% | 3.4% |
| Month 12 | 19.0% | 17.0% | 13.0% | 7.5% | 3.8% |
| Month 16 | 21.0% | 19.5% | 14.5% | 7.8% | 4.0% |
| Month 18 (endpoint) | 22.5% | 21.4% | 14.9% | 8.0% | 4.0% |
Table 4: Weight loss trajectory interpolated from clinical trial interim analyses. Tirzepatide data from SURMOUNT-1 (PMID: 35658024). Semaglutide from STEP-1 (PMID: 33404515). Liraglutide from SCALE (PMID: 25915532). Dulaglutide from AWARD-6 (PMID: 27311839).
5. Side effect onset and resolution timeline
Understanding when side effects begin and how long they typically last helps patients manage expectations during GLP-1 treatment. Data from our 1,200-patient survey:
| Side Effect | Incidence | Typical Onset | Peak Severity | Typical Resolution | % Resolved by Week 8 |
|---|---|---|---|---|---|
| Nausea | 38% | Day 1-3 | Week 1-2 | Week 4-8 | 82% |
| Diarrhea | 18% | Day 1-3 | Week 1 | Week 2-4 | 91% |
| Constipation | 14% | Week 1-2 | Week 2-4 | Week 4-8 | 76% |
| Vomiting | 12% | Day 1-3 | Week 1 | Week 2-4 | 88% |
| Fatigue | 9% | Week 1-2 | Week 2-4 | Week 4-6 | 85% |
| Decreased appetite | 71% | Day 1-3 | Week 2-8 | Persistent (desired) | N/A |
| Injection site reaction | 7% | Day 1 | Day 1-2 | Day 2-3 | 99% |
Table 5: Side effect timeline from our 2026 patient survey (n=1,200). Decreased appetite is an intended effect, not an adverse event. Resolution percentages reflect patients who reported the side effect resolving or becoming minimal by week 8.
6. Annual cost breakdown by medication
This table shows the total annual cost of treatment including medication, supplies, and required provider visits for both brand-name and compounded options:
| Option | Medication/mo | Provider Visits/yr | Supplies/yr | Annual Total | vs Compounded |
|---|---|---|---|---|---|
| Compounded Semaglutide (telehealth) | $147 | $0 (included) | $0 (included) | $1,764 | Baseline |
| Compounded Tirzepatide (telehealth) | $249 | $0 (included) | $0 (included) | $2,988 | +$1,224 |
| Wegovy (with insurance) | $300 | $240 | $120 | $3,960 | +$2,196 |
| Wegovy (without insurance) | $1,250 | $240 | $120 | $15,360 | +$13,596 |
| Zepbound (with insurance) | $350 | $240 | $120 | $4,560 | +$2,796 |
| Zepbound (without insurance) | $1,059 | $240 | $120 | $13,068 | +$11,304 |
| Saxenda (without insurance) | $1,350 | $240 | $120 | $16,560 | +$14,796 |
Table 6: Annual cost breakdown. Telehealth compounded pricing includes provider consultation and supplies. Insurance pricing assumes typical coverage with $25-50 copay. Provider visits assume 4 visits/year at $60/visit. Supplies include syringes and alcohol pads.
Related research
- The Complete GLP-1 Medication Guide 2026
- GLP-1 Cost Analysis 2026: 50 Telehealth Pharmacies Compared
- GLP-1 Patient Outcomes 2026: 6-Month Survey of 1,200 Patients
- GLP-1 Dosage Chart: Complete Titration Guide
- GLP-1 Medication Chart: Quick Comparison
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⚡ Limited spots this month — 50,000+ patients already started
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